Effect of Myeloma-Derived Microparticles on in Vitro Proliferation and Viability of Alloimmune Human Peripheral Blood Mononuclear Cells
نویسندگان
1 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Thran, Iran
2 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Thran, Iran
doi
10.18502/ijpho.v12i2.9074چکیده
Background: Microparticles (MPs) are small vesicles released from the cell membrane. Accordingly, these contain active molecules to mediate biological processes, including cell proliferation and cell cycle progression. The fusion of myeloma cell lines with immunized B lymphocytes is a critical step of hybridoma technology. MPs modulate lymphoproliferation, thereby facilitating B cell expansion and ...
