Comparative Analysis of the Effects of Valproic Acid and Tamoxifen on Proliferation, and Apoptosis of Human Hepatocellular Carcinoma WCH 17 CellLin

نویسندگان
Kavoosi, Fraidoon ID 1
Sanaei, Masumeh ID 2

1 Research Center for Non-communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran

2 Research Center for Non-communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran

doi
چکیده

Background: Histone deacetylation of tumor suppressor genes such as estrogen receptor alpha (ERα) can induce cancer, which is reversible by epi-drugs such as valproic acid (VPA). The previous result indicated that tamoxifen (TAM) induced apoptosis in hepatocellular carcinoma (HCC). This study was designed to assess the apoptotic and antiproliferative effects ...

کلیدواژه‌ها
Hepatocellular Carcinoma, Tamoxifen, Valproic acid