Synergistic Anti-Cancer Effects of Second-Generation Proteasome Inhibitor Carfilzomib with Doxorubicin and Dexamethasone Via p53-Mediated Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cells
نویسندگان
1 Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
2 Ministry of Health and Medical Education, Deputy of Management and Resources Development, Tehran, Iran
3 Department of Hematology and Blood Banking Faculty of Allied Medicine Iran University of Medical Sciences
4 Department of Hematology and Blood Banking Faculty of Allied Medicine Iran University of Medical Sciences
5 Department of Hematology and Blood Banking Faculty of Allied Medicine Iran University of Medical Sciences
6 Department of Hematology and Blood Banking Faculty of Allied Medicine Iran University of Medical Sciences
doi
10.18502/ijpho.v13i2.12339چکیده
Background: The ubiquitin-proteasome system (UPS) plays a crucial role in regulating the levels and functions of a large number of proteins in the cell, which are important for cancer cell growth and survival. The proteasome is highly activated in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), which is the most common malignancy in ...
