DNA Methylation and the Expression of the Tumor-Suppressor Genes Protocadherin-10 and Reprimo in Pediatric Acute Lymphoblastic Leukemia

نویسندگان
Moradi, Zahra ID 1
Azad, Mehdi ID 2
Chahrdovali, Bahram ID 3
Zaker, Farhad ID 4
Barati, Mahmood ID 5
Safari, Alieh ID 6
Rezvany, Mohammad reza ID 7

1 Department of Hematology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

2 Department of Medical laboratory Sciences, Qazvin University of Medical Sciences, Qazvin, Iran.

3 Tehran University of Medical Sciences

4 Iran University of Medical Sciences

5 Department of Medical Biothechnology, Faculty of allied Medicine, ,Iran University of Medical Sciences, Tehran, Iran.

6 Department of Pediatrics, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran Iran

7 Iran University of Medical Sciences

doi
10.18502/ijpho.v13i2.12342
چکیده

Background: Acute lymphoblastic leukemia (ALL) is the most prevalent hematologic malignancy among children. DNA methylation is well known to play a role in the initiation and progression of cancer. This research aimed to characterize the epigenetic inactivation and gene expression of Protocadherin-10 (PCDH10) and Reprimo (RPRM) in pediatric acute lymphoblastic leukemia, ...

کلیدواژه‌ها
Acute lymphoblastic leukemia, Methylation, PCDH10, RPRM