The Evaluation of the Role of Several Genes (BUB1, BUB1B, and TOP2A) and the Related Signaling Pathway in the Pathogenesis of Acute Lymphocytic Leukemia (ALL): Combination of in Silico and Experimental Analysis
نویسندگان
1 Department of Ophthalmology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran - Department of Ophthalmology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Assistant Professor of Internal Medicine, Department of Internal Medicine, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran - Assistant Professor of Internal Medicine, Department of Internal Medicine, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran
3 Assistant Professor of Hematology & Oncology, Department of Internal Medicine, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran - Assistant Professor of Hematology & Oncology, Department of Internal Medicine, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran
4 Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran - Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
5 Shahid Sadoughi University of Medical Sciences, Yazd, Iran - Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6 Department of Laboratory Hematology and Blood Bank, School of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran - Department of Laboratory Hematology and Blood Bank, School of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7 Department of Laboratory Hematology and blood transfusion, School of Allied Medical Sciences, Lorestan University of Medical Sciences, Khorramabad, Iran - Department of Laboratory Hematology and blood transfusion, School of Allied Medical Sciences, Lorestan University of Medical Sciences, Khorramabad, Iran
doi
10.18502/ijpho.v15i3.18921چکیده
Background: Acute lymphoblastic leukemia (ALL) is one of the most common cancers in children, which causes the death of many patients. Nowadays, bioinformatics approaches are widely used to identify factors involved in the pathogenesis of diseases. Given the extent of molecular pathways and genes involved in these pathways, the use ...
