Beyond the Blockage: A Deep Dive into the Pathogenesis of Vaso-Occlusive Crisis in Sickle Cell Disease
نویسندگان
1 Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran - Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2 Department of Hematology, Paramedical School of Science, Ilam University of Medical Sciences, Ilam, Iran - Department of Hematology, Paramedical School of Science, Ilam University of Medical Sciences, Ilam, Iran
3 Department of Anesthesiology, Rasoul-Akram Medical Center, Iran University of Medical Sciences (IUMS), Tehran, Iran - Department of Anesthesiology, Rasoul-Akram Medical Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
4 Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran - Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 Alborz University of Medical Sciences, Alborz, Iran - Alborz University of Medical Sciences, Alborz, Iran
doi
10.18502/ijpho.v15i3.18922چکیده
Vaso-occlusive crisis (VOC) is the hallmark and most debilitating complication of sickle cell disease (SCD), yet its pathophysiology is multifactorial and not completely understood. This review examines the molecular and cellular events that drive VOC, highlighting the synergistic interaction between hypoxia, inflammation, and coagulation. Recurrent deoxygenation triggers hemoglobin S polymerization, causing ...
