Frequency of C282Y and H63D Mutations of HFE Gene and Their Correlation with Iron Status in Iranian Beta-Thalassemia Major Patients

نویسندگان
Farshdousti Hagh , Majid ID 1
Kamali , Koorosh ID 2
Soltanpour , Mohammad Soleiman ID 3
Jafari , Gholam Ali ID 4
Davari , Kambiz ID 5

1 Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

2 Department of Public Health, School of Public of Health, Zanjan University of Medical Sciences, Zanjan, Iran.

3 Department of Medical Laboratory Sciences, School of Paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran

4 Department of Medical Laboratory Sciences, School of Paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran

5 Department of Pediatric, School of Medical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran

doi
چکیده

Background: Co-inheritance of hemochromatosis (HFE) gene mutations may play an essential role in the pathogenesis of iron overload in beta-thalassemia major (BTM) patients. The present study aimed to investigate the prevalence of HFE C282Y and H63D mutations in BTM patients and their correlation with some demographic data and biochemical iron ...

کلیدواژه‌ها
Beta-Thalassemia, C282Y, H63D, Hemochromatosis, HFE Mutation