Effect of Cassiopea andromeda Venom on P15INK4b, P21 WAF1/CIP1, P53, DNA methyltransferase 1, and Bcl-2 Genes Expression, Apoptosis Induction, and Cell Growth Inhibition in Acute Promyelocytic Leukemia NB4 Cell line
نویسندگان
1 Department of hematology and blood banking, Bushehr University of medical sciences, Bushehr, Iran.
2 Department of hematology and blood banking, Bushehr University of medical sciences, Bushehr, Iran. Salman Farsi Hospital of Bushehr, Bushehr, Iran.
3 Department of hematology and blood banking, Bushehr University of medical sciences, Bushehr, Iran.
4 Department of hematology and blood banking, Bushehr University of medical sciences, Bushehr, Iran.
5 The Persian Gulf Marine Biotechnology Research Center, the Persian Gulf Biomedical Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.
doi
10.18502/ijpho.v11i2.5842چکیده
Background: One of the acute hematologic malignancies is acute promyelocytic leukemia (APL) that resulted in translocation of chromosomes 15 and 17, t (15; 17), and cessation in the maturation of myeloid cell line, and ultimate aggregation of neoplastic promyelocytes. Regarding that appetence of using herbal and marine medicine studies is increasing, ...
