Assessment of Thiopurine–based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia

نویسندگان
Jafariyan , M ID 1
Khatami , S ID 2
Azimi , F ID 3
Mortazavi , Y ID 4
Azad , M ID 5

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چکیده

For the past half century, thiopurines have earned themselves a reputation as effective anti-cancer and immunosuppressive drugs. Thiopurine S-methyltransferase (TPMT) is involved in the metabolism of all thiopurines and is one of the main enzymes that inactivates mercaptopurine. 6-MP is now used as a combination therapies for maintenance therapy of children with ...

کلیدواژه‌ها
Acute lymphoblastic leukemia, 6-Mercaptopurine, 6-Thioguanine, Azathioprine, Myelosuppression, polymorphism