Promoter Methylation and Gene Expression in Human CD34+ Stem Cells Derived Erythroid Lineage by MicroRNA
نویسندگان
1 Department of pathology, School of medicine, Kashan University of Medical Sciences, Kashan, Iran
2 Hematology-Oncology and Stem cell Transplantation Research Center, Tehran university of Medical Science, Tehran, Iran
3 Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
4 Department of Immunology, Qazvin University of Medical Sciences, Qazvin, Iran
5 Department of Hematology, Faculty of Allied Medicine, Tehran University of Medical sciences, Tehran, Iran
6 Stem Cell Research Center, Department of Biochemistry, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
doi
چکیده
Background: Stem Cell differentiation is a process composed of vast variety of factors which are controlled by a network of certain mechanisms. This study aims to determine the possible role of DNA methylation, a potent regulator of VHL, ECAD and RUNX3 genes during Erythroid differentiation driven by miR-451. Materials and Methods: To determine ...
