Evaluating the expression of LKB1, SHMT1, and GLDC genes in Acute Lymphoblastic Leukemia patients
نویسندگان
1 Assistant professor, Department of Genetics, Faculty of Advanced science and Technology, Tehran Medical sciences, Islamic Azad university, Tehran, Iran - Assistant professor, Department of Genetics, Faculty of Advanced science and Technology, Tehran Medical sciences, Islamic Azad university, Tehran, Iran
2 Department of Hematology and Blood Bank, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran - Department of Hematology and Blood Bank, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Genetics, Faculty of Advanced science and Technology, Tehran Medical sciences, Islamic Azad university, Tehran, Iran - Department of Genetics, Faculty of Advanced science and Technology, Tehran Medical sciences, Islamic Azad university, Tehran, Iran
4 Department of Hematology and Blood Bank, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran - Department of Hematology and Blood Bank, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
doi
10.18502/ijpho.v14i3.15991چکیده
Background: Epigenetic changes in cancer cells have an immense effect on tumorigenesis. As a tumor suppressor and an epigenetic regulator, liver kinase B1 (LKB1) reduces gene methylation by downregulating metabolic pathways such as the serine-glycine pathway. This study seeks to examine the gene expression levels of serine hydroxymethyltransferase 1 (SHMT1) and glycine ...
