Pediatric Myelofibrosis: A Rare Entity Posing a Diagnostic Challenge

نویسندگان
Sharma, Kusha ID 1
Sharma, Sunita ID 2
Shukla, Shailaja ID 3
Parakh, Nupur ID 4
Puri, Vandana ID 5

1 Associate Professor, Department of Pathology, Lady Hardinge Medical College & Associated SSK & KSC Hospitals, New Delhi - Associate Professor, Department of Pathology, Lady Hardinge Medical College & Associated SSK & KSC Hospitals, New Delhi

2 Associate Professor, Department of Pathology, Lady Hardinge Medical College & Associated SSK & KSC Hospitals, New Delhi - Associate Professor, Department of Pathology, Lady Hardinge Medical College & Associated SSK & KSC Hospitals, New Delhi

3 Associate Professor, Department of Pathology, Lady Hardinge Medical College & Associated SSK & KSC Hospitals, New Delhi - Associate Professor, Department of Pathology, Lady Hardinge Medical College & Associated SSK & KSC Hospitals, New Delhi

4 Department of Pediatrics, Kalawati Saran Children’s Hospital, New Delhi - Department of Pediatrics, Kalawati Saran Children’s Hospital, New Delhi

5 Associate Professor, Department of Pathology, Lady Hardinge Medical College & Associated SSK & KSC Hospitals, New Delhi - Associate Professor, Department of Pathology, Lady Hardinge Medical College & Associated SSK & KSC Hospitals, New Delhi

doi
10.18502/ijpho.v14i3.15993
چکیده

Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders showing proliferation of one or more myeloid lineages. These disorders are characterized by Janus Kinase 2 (JAK2 V617F), Myeloproliferative leukemia (MPL), and Calreticulin (CALR) gene mutations and are seen more commonly in the elderly. These pathognomonic mutations are often absent in children and ...

کلیدواژه‌ها
Leukemia, Myelofibrosis, Primary, Secondary