The Effect of Platelet Lysate on Expansion and Differentiation Megakaryocyte Progenitor Cells from Cord Blood CD34+ enriched Cells

نویسندگان
Hassanzadeh, Ali ID 1
Naimi , Adel ID 2
Abdolahi, Sepehr ID 3
Zamani, Majid ID 4
Yaghoubi, Yoda ID 5
Yousefi, Mehdi ID 6
Aghebati-Maleki, Leili ID 7

1 Department of Tissue Engineering and Applied Cell Sciences, Tehran University of Medical Sciences, Tehran, Iran

2 Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran

3 Department of Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran

4 Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

5 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

6 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

7 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

doi
10.18502/ijpho.v11i3.6563
چکیده

Background: Umbilical cord blood hematopoietic stem cells (UCB-HSCs) are an attractive source for transplantation. The generation of megakaryocyte-committed cells could lead to shorten period of thrombocytopenia after HSCs transplantation. Platelet lysate (PL) unlike fetal bovine serum (FBS) can prevent immune problems as well as avert transmission of certain diseases to ...

کلیدواژه‌ها
Cord Blood Stem Cell Transplantation, Hematopoietic Stem Cells, Megakaryocyte Progenitor Cells, Platelet-Derived Growth Factor