Effects of 5-aza-2ˈ-deoxycytidine and Valproic Acid on Epigenetic-modifying DNMT1 Gene Expression, Apoptosis Induction and Cell Viability in Hepatocellular Carcinoma WCH-17 cell line
نویسندگان
1 Research Center for Non-communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran
2 Research Center for Non-communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran
doi
10.18502/ijpho.v9i2.607چکیده
Background: DNA molecule of the eukaryotic cells is found in the form of a nucleoprotein complex named chromatin. Two epigenetic modifications are critical for transcriptional control of genes, including acetylation and DNA methylation. Hypermethylation of tumor suppressor genes is catalyzed by various DNA methyltransferase enzymes (DNMTs), including DNMT1, DNMT2, and DNMT3. ...
