Synthesis of Dihydropyrano[3,2-c]chromenes in the Presence of Effective Acid–Base Nano Catalyst (3-Aminopyridine/Go) and Evaluation of Their Toxicity against Cancer Cells
نویسندگان
1 Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran - Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Hematology and Oncology Research Center, Noncommunicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran - Hematology and Oncology Research Center, Noncommunicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran - Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4 Chemical Engineering (Biotecnology), Faculty of Engineering, University of Tehran, Iran - Chemical Engineering (Biotecnology), Faculty of Engineering, University of Tehran, Iran
5 Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran - Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
6 Department of pharmacology, School of medicine, Tehran University of Medical Sciences, Tehran, Iran - Department of pharmacology, School of medicine, Tehran University of Medical Sciences, Tehran, Iran
doi
10.18502/ijpho.v16i2.21344چکیده
Background: Dihydropyrano[3,2-c]chromenes are oxygen-containing heterocycles with reported anticancer potential, yet green and efficient synthetic methods remain limited. Conventional catalysts often involve harsh conditions or low reusability. This study aimed to develop a sustainable, high-yield synthesis of chromenes via a novel acid–based nanocatalyst (GO/3-aminopyridine), and to evaluate the cytotoxicity of selected derivatives against ...
