Plasma Endocan as a Biomarker of Endothelial Dysfunction in Egyptian Children with Beta-Thalassemia Major: A Single-Center Analysis
نویسندگان
1 Medical laboratory Technology Department, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria - Medical laboratory Technology Department, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria
2 Pediatrics Department, Faculty of Medicine, Helwan University, Cairo, Egypt - Pediatrics Department, Faculty of Medicine, Helwan University, Cairo, Egypt
3 Hematology Department, Medical Research Institute, Alexandria University - Hematology Department, Medical Research Institute, Alexandria University
4 Pediatrics Department, Faculty of Medicine, Helwan University, Cairo, Egypt - Pediatrics Department, Faculty of Medicine, Helwan University, Cairo, Egypt
doi
10.18502/ijpho.v16i2.21347چکیده
Background: Beta-thalassemia major (β-TM) is a transfusion-dependent disorder associated with iron overload and endothelial dysfunction. Endocan is a proteoglycan secreted by endothelial cells and has been proposed as an indicator of endothelial activation and inflammation. Children with β-TM face various problems, such as glomerular and tubular degeneration, cardiomyopathy, and endothelial damage, which ...
