Immune Thrombocytopenic Purpura in Patients with Inborn Errors of Immunity: A Narrative Review
نویسندگان
1 Department of Pediatrics, Shahid Sadughi Haspital, Shahid Saduoghi University of Medical Sciences, Yazd, Iran 2. Hematology and Oncology Research Center, Noncommunicable Diseases Research Institute, Shahid Saduoghi University of Medical Sciences, Yazd, Iran 3. Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran - Department of Pediatrics, Shahid Sadughi Haspital, Shahid Saduoghi University of Medical Sciences, Yazd, Iran
doi
10.18502/ijpho.v16i2.21349چکیده
Immune thrombocytopenic purpura (ITP) is one of the autoimmune disorders characterized by isolated thrombocytopenia due to immune-mediated platelet destruction. The pathogenesis of ITP is complex, involving autoantibodies against platelet glycoproteins (GPIIb/IIIa, GPIb/IX), excessive T helper1, T helper10, Thelper17 (TH1-TH0-TH17) polarization, Treg cell deficiency, and cytotoxic destruction of platelets. Cytotoxic CD8+ T-cell-mediated platelet ...
