Detection of R882 Mutations in DNMT3A Gene in Acute Myeloid Leukemia: A Method Comparison Study

نویسندگان
Nikbakht , Mohsen ID 1
toosi, Bahareh ID 2
zaker, farhad ID 3
kazemi, Ahmad ID 4
TEREMMAHI ARDESTANI, MAJID ID 5
chahardouli, bahram ID 6
Mohammadi , Saeed ID 7
rostami, shahrbano ID 8

1 Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran University of medical sciences, Tehran, Iran.

2 Department of hematology, School of allied medical sciences, Iran university of medical sciences

3 Department of hematology, School of allied medical sciences, Iran university of medical sciences

4 Department of hematology, School of allied medical sciences, Iran university of medical sciences

5 Department of hematology, School of allied medical sciences, Iran university of medical sciences

6 Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center

7 Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran University of medical sciences, Tehran, Iran

8 Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center

doi
چکیده

Background: Somatic mutations in the hotspot region of the DNA-methyltransferase 3A (DNMT3A) gene were recurrently identified in acute myeloid leukemia (AML). It is believed that DNMT3A mutations confer an adverse prognosis for AML patients. These lines of evidence support the need for a rapid and cost-efficient method for the detection of ...

کلیدواژه‌ها
Acute Myeloid Leukemia, DNA Methyltransferase 3A, Sequencing