The Effect of 6-Thioguanine on Proliferation, Viability and Expression of the Genes DNMT 3A, DNMT 3B and HDAC3 in Lymphoid Cancer Cell Line Nalm6
نویسندگان
1 Department of Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Hematology & Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Department of Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
doi
10.18502/ijpho.v10i1.2167چکیده
Background: 6-thioguanine (6-TG) is one of the thiopurine drugs with successful use in oncology, especially for acute lymphoblastic leukemia (ALL). 6-TG is proposed to act as an epigenetic drug affecting DNA methylation. The aim of this study was to clarify the effect of 6-TG on the proliferation, viability and expression ...
