Use of Four-Color Flow Cytometric Assay for Discrimination of Hematogone from Lymphoblast: Critical Issue for MRD Assessment in B-ALL Patients

نویسندگان
Shahabi Satlsar , Esmaeil ID 1
Agaeipour, Mahnaz ID 2
Mohammadi , Mohammad Hossein ID 3
Gholampour, Roohollah ID 4
Allahbakhshian Farsani, Mehdi ID 5
Mohseni, Alireza ID 6
Mosleh, Mohammad ID 7
Mehrpouri , Mahdieh ID 8
Jadali, Farzaneh ID 9

1 Department of Laboratory Hematology and Blood Banking, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Takhte Tavous Pathobiology Laboratory, Flow Cytometry Department, Tehran, Iran

3 Department of Laboratory Hematology and Blood Banking, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Takhte Tavous Pathobiology Laboratory, Flow Cytometry Department, Tehran, Iran

5 Department of Laboratory Hematology and Blood Banking, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6 Laboratory Hematology and Blood Banking, Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran

7 Department of Laboratory Hematology and Blood Banking, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

8 Department of Laboratory Hematology and Blood Banking, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

9 Takhte Tavous Pathobiology Laboratory, Flow Cytometry Department, Tehran, Iran

doi
10.18502/ijpho.v10i1.2166
چکیده

Background: Hematogones are normal B-cell precursor which can be seen in different physiological and pathological conditions. Due to variation in B-cell acute lymphoblastic leukemia (B-ALL) blasts immunophenotyping and interference of hematogones in minimal residual disease (MRD) assessment, precise discrimination of hematogones is very crucial.  The purpose of this study was ...

کلیدواژه‌ها
B-ALL, Hematogone, Lymphoblast, MRD