Whole Exome Sequencing for Mutation Screening in Hemophagocytic Lymphohistiocytosis
نویسندگان
1 Department of Medical Biotechnology, School of Allied Medicine, Iran University of Medical Science. Tehran- Iran
2 Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran- Iran
3 Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran-Iran
4 Department of Medical Biotechnology, School of Allied Medicine, Iran University of Medical Science, Tehran-Iran
5 Department of Medical Biotechnology, School of Allied Medicine, Iran University of Medical Science. Tehran- Iran
6 Department of Laboratory Sciences, School of Allied Medical Sciences, Zahedan University of Medical Sciences, Zahedan- Iran
7 Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran-Iran
doi
10.18502/ijpho.v10i1.2168چکیده
Background: Hemophagocytic lymphohistiocytosis (HLH) is an immune system disorder characterized by uncontrolled hyper-inflammation owing to hypercytokinemia from the activated but ineffective cytotoxic cells. Establishing a correct diagnosis for HLH patients due to the similarity of this disease with other conditions like malignant lymphoma and leukemia and similarity among its two forms ...
