Gene Expression and Promoter Methylation Status of VHL, Runx-3, E-cadherin, P15 and P16 Genes During EPO-Mediated Erythroid Differentiation of CD34+ Hematopoietic Stem Cells

نویسندگان
Goudarzi , Mehdi ID 1
Mobarra , Naser ID 2
Sahmani , Mehdi ID 3
Dehghanifard , Ali ID 4
Eskandari , Fatemeh ID 5
Pourkarim , Hoda ID 6
Pakpour , Amir H ID 7
Kalantari , Nasim ID 8
Gholamreza , Khamisipour ID 9
Azad, Mehdi ID 10

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چکیده

Background: VHL (von Hippel-Lindau), Runx-3 (Runt-related transcription factor 3), E-cadherin (Epithelial cadherin), P15 (INK4a, cyclin dependent kinase inhibitor), and P16 (INK4b) genes are essential in hematopoiesis. The aim of this study was to explore the correlation between gene expression and promoter methylation in CD34+ stem cells before and after differentiation ...

کلیدواژه‌ها
Differentiation, EPO, Hematopoietic Stem Cells