Methylenetetrahydrofolate Reductase Polymorphisms in Iranian Patients with Glanzmann’s Thrombasthenia

نویسندگان
Kazemzadeh, Shima ID 1
Mohammadi, Rezvan ID 2
Shadkam Farokhi, Fatemeh ID 3
Ala, Fereydoun ID 4
Shafiian, Alireza ID 5
Faranoush, Mohammad ID 6
Farsinejad, Alireza ID 7

1 Department of Laboratory Hematology and Blood Banking, Faculty of allied medicine, Kerman University of Medical Sciences, Kerman, Iran.

2 Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.

3 Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.

4 Professor of Hematology, Iranian Comprehensive Hemophilia Care Centre, Tehran, Iran.

5 School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.

6 Pediatric growth and development research center, Endocrinology institute, Iran university of medical science, Tehran, Iran.

7 Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

doi
چکیده

Background: The most common polymorphisms identified in the Methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C lead to defective activity of this enzyme and increase the risk of venous and arterial thrombosis. There are limited investigations regarding the effects of thrombogenic polymorphisms on the clinical phenotypes of rare hereditary hemorrhagic disorders ...

کلیدواژه‌ها
Glanzmann's thrombasthenia, Polymorphism, Methylenetetetrahydrofolate reductase, Rare hereditary bleeding disorders