The effect of Ganoderic Acid A on miR-17-5p and miR-181b expression level and apoptosis induction in human leukemia Nalm-6 cells

نویسندگان
Taheri , Simin ID 1
Zare , Farahnaz ID 2
Mortazavie , Faezeh ID 3
Tandel , Parisa ID 4
Tamaddon, Ghoalmhossein ID 5

1 Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

2 Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

3 Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

4 Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

5 Diagnostic Laboratory Sciences and Technology Research Center, Paramedical School, Shiraz, University of Medical Sciences, Shiraz, Iran

doi
10.18502/ijpho.v12i3.10058
چکیده

Background: In various cancers, Ganoderic Acid A (GAA), an active triterpenoid derived from Ganoderma lucidum, has been proved to show potent anti-tumor effects. However, the possible impacts of GAA on the human leukemia cell line (Nalm-6) are not fully elucidated. Therefore, this research aimed to study the antineoplastic effect of GAA ...

کلیدواژه‌ها
Apoptosis, Ganoderic Acid A, MiR-17-5p, MiR-181b, Nalm-6 cells