DNA methylation of tumor suppressor genes in hepatocellular carcinoma
نویسندگان
1 Research Center for Non-communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran
2 Research center for non-communicable diseases, Jahrom University of medical sciences, Jahrom, Iran
3 Department of Microbiology, School of Medicine; Jahrom University of Medical Sciences, Jahrom, Iran
doi
10.18502/ijpho.v10i4.4410چکیده
The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common ...
