Effect of 5'-fluoro-2'-deoxycytidine and sodium butyrate on the genes of the intrinsic apoptotic pathway, p21, p53, cell viability, and apoptosis in human hepatocellular carcinoma cell lines
نویسندگان
1 Research center for non-communicable diseases, Jahrom University of medical sciences, Jahrom, Iran
2 Research center for non-communicable diseases, Jahrom University of medical sciences, Jahrom, Iran
3 Student of Research Committee, Jahrom University of medical sciences, Jahrom, Iran
doi
10.18502/ijpho.v11i4.7163چکیده
Backgrounds: Epigenetic regulation such as DNA methylation plays a major role in chromatin organization and gene transcription. Additionally, histone modification is an epigenetic regulator of chromatin structure and influences chromatin organization and gene expression. The relationship between DNA methyltransferase (DNMTs) expression and promoter methylation of the tumor suppressor genes (TSGs) has ...
