Effect of 5-aza-2′-deoxycytidine on p16INK4a, p14ARF, p15INK4b Genes Expression, Cell Viability, and Apoptosis in PLC/PRF5 and MIA Paca-2 Cell Lines

نویسندگان
Sanaei , Masumeh ID 1
Mohammadi , Maedeh ID 2
Kavoosi , Fraidoon ID 3
Khanezad, Maryam ID 4

1 Research center for non-communicable diseases, Jahrom University of medical sciences, Jahrom, Iran

2 Student of Research Committee, Jahrom University of medical sciences, Jahrom, Iran

3 Research center for non-communicable diseases, Jahrom University of medical sciences, Jahrom, Iran

4 Department of anatomy, school of medicine, Tehran University of medical science, Tehran, Iran.

doi
10.18502/ijpho.v9i4.1570
چکیده

Background: Mammalian cell division is regulated by a complex includes cyclin-dependent kinases (Cdks) and cyclins, Cdk/cyclin complex. The activity of the complex is regulated by Cdk inhibitors (CKIs) compressing CDK4 (INK4) and CDK-interacting protein/kinase inhibitory protein (CIP/KIP) family. Hypermethylation of CKIs has been reported in various cancers. DNA methyltransferase inhibitors (DNMTIs), ...

کلیدواژه‌ها
Apoptosis, 5-aza-2'-deoxycytidine-5'-monophosphate, Gene expression, Viability