Evaluation of JAK2V617F mutation prevalence in myeloproliferative neoplasm by AS-RT-PCR

نویسندگان
Chahardouli, B ID 1
Zaghal, A ID 2
Mousavi, SA ID 3
Bahar, B ID 4
Ghavamzadeh, A. ID 5
Karimzadeh, P ID 6
Ghaffari, SH. ID 7
Einollahi, N ID 8
Dargahi, H ID 9
Alimoghaddam, K. ID 10

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چکیده

Abstract Objective JAK2 is a non-receptor tyrosine kinase that plays a major role in myeloid disorders. JAK2V617F mutation is characterized by a G to T transverse at nucleotide 1849 in exon 12 of the JAK2 gene, located on the chromosome 9p, leading to a substitution of valine to phenylalanine at amino acid position 617 in the ...

کلیدواژه‌ها
JAK2 mutation, AS-RT-PCR, polycythemia vera, essential thrombocythemia, primary myelofibrosis