MicroRNAs as a New Molecular Biomarker for Diagnosis and Prognosis of T-cell Acute Lymphoblastic Leukemia (T-ALL): A Systematic Review

نویسندگان
Naji , Parisa ID 1
Khatami , Mehri ID 2
Chamani , Reyhane ID 3
Heidari , Mohammad Mehdi ID 4
Zare-Zardini , Hadi ID 5

1 Department of Biology, Faculty of Science, Yazd University, Yazd, Iran

2 Department of Biology, Faculty of Science, Yazd University, Yazd, Iran

3 Department of Biology, Faculty of Science, Yazd University, Yazd, Iran

4 Department of Biology, Faculty of Science, Yazd University, Yazd, Iran

5 Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

doi
چکیده

MicroRNAs (miRNAs, miRs) are small endogenous non-coding RNAs that regulate the expression of protein-encoding genes at the post-transcriptional level. Several studies have described the role of miRNAs in T-cell acute lymphoblastic leukemia (T-ALL), including tumor suppressor and oncogenic miRNAs. Down-regulation of miRNA expression is a prominent feature of human malignancy. This ...

کلیدواژه‌ها
T-cell Acute Lymphoblastic Leukemia, microRNAs, Oncogenic miRNAs, Tumor Suppressor miRNAs, Biomarkers