Investigation of Punicic Acid Effects on Matrix Metalloproteinase Genes Expression in Bovine Fibroblast like-Synoviocytes as a Model of Osteoarthritis
نویسندگان
1 1- Biotechnology Research Center, Payame Noor University, Tehran, Iran
2 1- Biotechnology Research Center, Payame Noor University, Tehran, Iran
3 3- Department of Biology, Payame Noor University, Tehran, Iran
4 Center of Food and Drug Control References Laboratories (CFDCRL), Food and Drug Organization (FDO), Ministry of Health and Medical Education (MOH), Tehran, Iran
doi
چکیده
Background: Osteoarthritis (OA) is a progressive, age-associated disease that is characterized with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane. Considering the complications of common treatments of OA, including non-steroidal anti-inflammatory drug (NSAIDs) and corticosteroids, investigating new treatments for this disorder is crucial. Recently, the role of matrix metalloproteinases ...
