Melatonin Versus Duloxetine for Managing Symptoms of Osteoarthritis: A Randomized Controlled Trial Study

نویسندگان
Delkash, Parisa ID 1
Moradi Shahrbabak, Hamideh ID 2
Ariana, Shideh ID 3
Vaziri-Harami, Roya ID 4
Heidari Almasi, Minoo ID 5

1 Clinical Research Development Unit, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Clinical Research Development Unit, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Perinatology Division, Department of Obstetrics and Gynecology, School of Medicine, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Clinical Research Development Unit, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 Clinical Research Development Unit, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

doi
10.32598/JROSJ.10.1.1597.1
چکیده

Background: Osteoarthritis (OA) is a degenerative joint disorder causing pain and disability. The present treatments are inadequate to improve the underlying pathogenesis of OA. Melatonin, because of its chondroprotective, anti-inflammatory, and antioxidant properties, may have a role in the management of OA. Duloxetine is presumed to modulate pain through serotonergic and noradrenergic ...

کلیدواژه‌ها
Osteoarthritis (OA), Melatonin, Duloxetine, Western Ontario and McMaster universities osteoarthritis index (WOMAC)