Severe Osteoarthritis of the Knee as an Early Symptom of Alkaptonuria: A Case Report
نویسندگان
1 Department of Orthopedics, Trauma and Hand Surgery, St. Marien Hospital, Siegen, Germany
2 Department of Orthopedics, Trauma and Hand Surgery, St. Marien Hospital, Siegen, Germany
doi
10.17795/soj-4547چکیده
Introduction: Alkaptonuria (AKU) is a very rare disease and occurs due to the deficiency of the enzyme homogentisate1, 2-dioxygenase (HGD) which results in ochronosis, a term used to describe the dark pigmentation of the tissues. Alkaptonuria affects mostly the knee joint followed by the hip as major weight bearing joints, where the ...
