Synovial Macrophage Polarization in Knee Osteoarthritis: A Narrative Mini-Review of an Emerging Biological Target
نویسندگان
1 Department of Orthopedic Surgery, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
2 Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
doi
10.32598/JROSJ.13.1.2743.1چکیده
Knee osteoarthritis (KOA) is increasingly recognized as a disease driven by low-grade inflammation in addition to mechanical degeneration. Among immune cells involved in joint homeostasis, synovial macrophages play a central role in modulating inflammatory responses. Recent evidence highlights the importance of macrophage polarization, particularly the imbalance between pro-inflammatory (M1) and anti-inflammatory (M2) ...
