A Meta-Analysis on the Prognostic and Predictive Role of Stem-like CD8+ T Cells in Cancer Immunotherapy: Correlating Clinical Outcomes

نویسندگان
Sharma, Sonika ID 1
Singh Matreja, Prithpal ID 2
Singh, Sudhir ID 3
Usha Kiran, Pothu ID 4

1 Department of Anatomy, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.

2 Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.

3 Department of Microbiology, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.

4 Department of Biochemistry, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.

doi
چکیده

Background: Stem-like CD8+ T cells, marked by TCF1 and PD-1, possess self-renewal and effector differentiation abilities, crucial for cancer immunotherapy. Despite tumor microenvironment constraints, their abundance often correlates with favourable outcomes. Aim: To assess the prognostic and predictive relevance of stem-like CD8+ T cells in patients receiving immunotherapy for cancer. Methodology: 721 ...

کلیدواژه‌ها
Cancer Immunotherapy, CD8 Positive T Lymphocytes, Immunologic Surveillance, Stem Cells, T Cell Exhaustion