Frequency of BCR-ABL Fusion Transcripts in Iranian Azeri Turkish patients with Chronic Myeloid Leukemia

نویسندگان
Bagheri, Morteza ID 1
Maleki, Davood ID 2
Abdi Rad, Isa ID 3
Eishi, Ali ID 4
Valizadeh, Nasim ID 5

1 Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran

2 Department of Hematology-Medical Oncology, Urmia University of Medical Sciences, Urmia, Iran.

3 Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran

4 Department of Medicine, Urmia University of Medical sciences, Urmia, Iran, Telephone: +98(441) 337-0234, Fax: +98(441) 346-9935

5 Department of Medicine, Urmia University of Medical sciences, Urmia, Iran, Telephone: +98(441) 337-0234, Fax: +98(441) 346-9935

doi
چکیده

Background: The Philadelphia chromosome (Ph) characterized by t (9; 22) (q34; q11.2) is a reciprocal translocation giving rise to a chimeric BCR-ABL fusion gene. Incidence of Ph chromosome is over 98% in Patients with Chronic Myeloid Leukemia (CML) and around 20% in acute lymphoblastic leukemia (ALL). The finding of this fusion gene is ...

کلیدواژه‌ها
BCR-ABL fusion gene, CML, a2b2 transcript, a2b3 transcripts, RT-PCR test