Glutathione Peroxidase as an Oxidative Stress and Insulin Resistance Marker in a group of Egyptian Patients with Normoglycemic Sickle Cell Disease

نویسندگان
Hamdy, Mona M. ID 1
Salama, Neviene ID 2
Elgammal, ID 3
Abdou, Doaa M. ID 4
Amrousy, Yasmine M. ID 5

1 Department of Pediatrics Medicine; Kasr Al Ainy, Faculty of Medicine, Cairo University, Cairo, Egypt

2 Department of Pediatrics Medicine; Kasr Al Ainy, Faculty of Medicine, Cairo University, Cairo, Egypt

3 Department of Pediatrics Medicine; Kasr Al Ainy, Faculty of Medicine, Cairo University, Cairo, Egypt

4 Department of Clinical and Chemical Pathology, Kasr Al Ainy, Faculty of Medicine, Cairo University, Cairo, Egypt

5 Department of Clinical and Chemical Pathology, Faculty of Medicine, Helwan University, Cairo, Egypt

doi
چکیده

Background: Sickle cell disease (SCD) which is characterized by abnormal hemoglobin structure has a carrier rate of 9-20% in Egypt. Reactive oxygen species (ROC) in SCD cause multiple organ injuries, endocrine complications and metabolic alteration such as insulin resistance (IR) in children and young adults. We aimed to determine the presence ...

کلیدواژه‌ها
Anemia, Sickle cell disease, Insulin resistance, Oxidative stress, Glutathione peroxidase, HOMA-IR