The Mitochondrial DNA 4977-bp Deletion in Patients with Colorectal Cancer: a Case-control Study in Iran

نویسندگان
Alaei, Fariba ID 1
Kamfar, Sharareh ID 2
Zaferani, Reza ID 3
Zeinali, Vahide ID 4

1 Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

doi
10.58209/ijbc.14.4.104
چکیده

Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide, and its occurrence can be ascribed to genetic susceptibility. Mitochondrial DNA 4977-bp (mtDNA 4977), as the most described mtDNA deletion, has been long proposed to be involved in various types of cancers. However, a few studies on mtDNA 4977-bp ...

کلیدواژه‌ها
Colorectal cancer, Mitochondrial DNA, Multiplex PCR, Gene deletion