The long-term outcome and efficacy of PR1/BCR-ABL multipeptides vaccination in chronic myeloid leukemia: results of a 7-year longitudinal investigation

نویسندگان
Ghaffari, Seyed H. ID 1
Ahmadvand, Mohammad ID 2
Hossaini, Elham ID 3
Yaghmaie, Marjan ID 4
Koohi, Roghieh ID 5
Ghashgha, Andisheh ie ID 6
Osfouri, Ebrahim ID 7
Bashash, Davood ID 8
Ghaffari, Parisa ID 9
Niavarani, Ahmadreza ID 10
Pourbagheri-Sigaroodi, Atieh ID 11
Mousavi, Seyed A. ID 12
Alimoghaddam, Kamran ID 13
Ghavamzadeh, Ardeshir ID 14

1 Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

3 Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

4 Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

5 Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

6 Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

7 Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

8 Department of Hematology and Blood Banking, School of Allied Medical Sciences Shahid Beheshti University of Medical Sciences, Tehran, Iran

9 Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

10 Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran

11 Department of Biotechnology, faculty of Advanced Sciences and Technology, Pharmaceutical sciences branch, Islamic Azad University (IAUPS), Tehran, Iran

12 Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

13 Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

14 Hematologic Malignancies Research Center, Tehran University of Medical Sciences, Tehran, Iran

doi
10.58209/ijbc.14.4.84
چکیده

Background: Although Imatinib has revolutionized the treatment of chronic myeloid leukemia (CML), not all patients reach complete remission and a considerable proportion of the patients develop resistance to Imatinib. Material and Methods: In an attempt to increase the tail on the survival curve, we conducted a Phase I/II study of PR1/BCR-ABL multipeptides ...

کلیدواژه‌ها
Multi-peptide vaccination, BCR-ABL, PR1 peptide, Chronic myeloid leukemia