Integrative In Silico and Experimental Analyses Reveal the Therapeutic Potential of miR-217-5p in Hepatocellular Carcinoma Through KRAS Suppression and p53 Activation
نویسندگان
1 Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing. Universitas Gadjah Mada, Yogyakarta, Indonesia
2 Department of Pharmacotherapy, Faculty of Medicine, Universitas Palangka Raya, Palangka Raya, Indonesia
3 Department of Pharmacology, Faculty of Medicine, Universitas Ahmad Dahlan, Yogyakarta, Indonesia.
4 Traditional health services unit of Sardjito Hospital, Tawangmangu, Indonesia.
5 Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
6 Study Program of Biotechnology, Universitas Gadjah Mada, Yogyakarta, Indonesia.
doi
چکیده
Background: Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, and dysregulation of microRNAs has been increasingly recognized as a critical driver in its pathogenesis. Among them, miR-217-5p has been reported as a tumor-suppressive miRNA, yet its molecular role and therapeutic potential in HCC remain largely unclear. Methods: In silico ...
