A Review of Newer Pathophysiological Insights into Pediatric Brain Tumors: Revisiting Maintenance and Metronomic Chemotherapy in Resource-Limited Settings
نویسندگان
1 Mahak Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Student Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. - USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran.
3 Health Services Management Department, Science and Research Branch, Islamic Azad University, Tehran, Iran.
4 Mahak Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Department of pediatrics, Tehran University of Medical Science, Tehran, Iran.
6 Lorestan University of Medical Sciences, Khorramabad, Iran. - Student Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
7 School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
8 Mahak Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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چکیده
Pediatric brain tumors remain a leading cause of morbidity and mortality worldwide, with management in developing countries particularly constrained by limited healthcare resources. This review highlights emerging concepts in tumor biology, particularly the roles of the tumor microenvironment (TME) and cancer stem cells (CSCs), which are increasingly recognized as critical drivers ...
