Effects of Topical Vitamin E Mouthwash in Preventing Oral Mucositis in Allogenic Hematopoietic Stem Cell Transplant Patients: A Double-Blind, Placebo-Controlled Trial
نویسندگان
1 Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran
2 Nanotechnology Research Centre, Tehran University of Medical Sciences
3 Nanomedicine and Biomaterial Lab, Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4 epartment of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
5 Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
6 Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran Research Center for Rational Use of Drugs, Tehran University of Medical Science, Tehran, Iran
7 Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
8 Department of Clinical Pharmacy, Faculty of Pharmacy, Guilan University of Medical Science, Guilan, Iran
9 Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
10 Hematology-Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
doi
چکیده
Background: Oral mucositis is considered a frequent complication of conditioning regimen in patients undergoing hematopoietic stem cell transplantation (HSCT). Mucositis develops due to direct and indirect damage to the epithelial cells and production of reactive oxygen species (ROS). Vitamin E has shown positive effects in reducing production of ROS or improving its ...
