Expression Analysis of Foxo3a Gene in Pediatric Acute Lymphoblastic Leukemia in Southern Iranian Population

نویسندگان
Nasiri, Mahboobeh ID 1
Mirzaei, Malihe ID 2
Karimi, Mehran ID 3

1 Department of Biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran

2 Department of Biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran

3 Department of Biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran

doi
چکیده

Background: Acute lymphoblastic leukemia (ALL), the most common childhood cancer with a peak incidence in children from 2-5 years old, might be associated with poor prognosis and resistance to therapy in specific cytogenetic backgrounds. FoxO3a, a member of the forkhead class ‘O’ (FoxO) transcription factors, is a main downstream target of PI3K/AKT pathway ...

کلیدواژه‌ها
FoxO3a, Pediatric ALL, Gene expression, PI3K/AKT pathway