Expression of Recombinant Coagulation Factor IX in Human Amniotic Membrane-derived Mesenchymal Stem Cells: A New Strategy to Gene Therapy of Hemophilia B

نویسندگان
Paridar, Mostafa ID 1
Amirizadeh, Naser ID 2
Abolghasemi, Hassan ID 3
Jalili, Mohammad Ali ID 4
Habibi Roudkenar, Mahyar ID 5
Amiri, Fatemeh ID 6

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چکیده

Background: Hemophilia B is an X-linked hereditary disorder of blood coagulation system which is caused by factor IX (FIX) deficiency. Factor IX is a plasma glycoprotein that participates in the coagulation process leading to the generation of fibrin. Replacement of factor IX with plasma-derived or recombinant factor IX is the conventional treatment ...

کلیدواژه‌ها
Hemophilia B, amnion membrane, mesenchymal stem cell, factor IX, gene therapy