Analysis of Expression Of SIRT1 Gene In Patients With Chronic Myeloid Leukemia Resistant To Imatinib Mesylate

نویسندگان
Ghotaslou, A ID 1
Ghasemi, A ID 2
Nadali, F ID 3
Abbasian, S ID 4

1 Tehran University of Medical Sciences

2 Tehran University of Medicaaal Sciences

3 Tehran University of Medical Sciences

4 Tehran University of Medical Sciences

doi
چکیده

Background: Chronic myeloid leukemia is a clonal myeloproliferative disease which is characterized by bcr/abl translocation. With the emergence of tyrosine kinase inhibitors such as imatinib mesylate, significant improvement has been made in treatment of this disease. However, drug resistance against this medicine is still an obstacle. SIRT1 is a gene with deacetylase ...

کلیدواژه‌ها
CML, Gene expression, SIRT1 gene, Drug resistance, Imatinib mesylate