NUDT15 genetic variants and 6-mercaptopurine intolerance in pediatric acute lymphoblastic leukemia: an updated review

نویسندگان
Siyadat, Payam ID 1
Yazdandoust, Ehsan ID 2
Sheikhi, Maryam ID 3
Ayatollahi, Hossein ID 4

1 Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

2 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran

3 Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4 Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

doi
10.58209/ijbc.14.2.75
چکیده

Acute lymphoblastic leukemia (ALL) accounts for nearly 30% of pediatric cancers. The maintenance treatment for ALL comprises daily oral 6-mercaptopurine (6-MP) and weekly methotrexate (MTX). 6-MP is a purine analog that can significantly improve the long-term survival of ALL patients. Despite more than 90% of 5-year survival of childhood ALL in ...

کلیدواژه‌ها
6-Mercaptopurine, NUDT15, Leukopenia, polymorphism, pediatric, acute lymphoblastic leukemia