High Variability in HLA-DRB1*03, a Predisposing Allele in Acute Lymphoblastic Leukemia

نویسندگان
Idris, Siti Zuleha ID 1
Chang, Kian Meng ID 2
Osman, Raudhawati ID 3
Dhaliwal, Jasbir Singh ID 4
Hassan, Norfarazieda ID 5
Mohd Ibrahim, Hishamshah ID 6
Abdullah, Maha ID 7

1 Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

2 Department of Hematology, Hospital Ampang, Clinical Hematology Laboratory, Jalan Mewah Utara, Pandan Mewah, Ampang, Selangor 68000, Malaysia

3 Hematology Unit, Hospital Kuala Lumpur, Jalan Pahang, 50586 Wilayah, Persekutuan Kuala Lumpur, Malaysia

4 Allergy and Immunology Research Centre, Institute for Medical Research, 50588 Jalan Pahang, Kuala Lumpur

5 UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia

6 Pediatric Department, Hospital Kuala Lumpur, 50586 Wilayah, Persekutuan Kuala Lumpur, Malaysia

7 Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

doi
10.61186/ijbc.16.2.24
چکیده

Acute lymphoblastic leukemia (ALL) remains a significant health concern, particularly in children, with genetic predisposition playing a crucial role in its etiology. Among the predisposing HLA Class II alleles, —DRB1*03 has emerged as a notable candidate associated with increased susceptibility to ALL. This study aims to investigate the extent of variability within the ...

کلیدواژه‌ها
Human leukocyte antigen, HLA-DRB1*03, HLA class II, Acute lymphoblastic leukemia, Pre-B ALL