Evaluation of the CpG-island DNA Methylation Pattern in Promoter of DNMT1 and CDX2 Genes in Different Phases of Acute Myeloid Leukemia; A Follow-up Study
نویسندگان
1 Department of Medical Biotechnology, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
2 Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
3 Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
4 Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5 Department of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6 Department of Medical Biotechnology, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. - Department of Immunology, Pasteur Institute of Iran, Tehran, Iran.
7 Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
doi
10.61186/ijbc.16.3.40چکیده
Background: Aberrant DNA methylation is a key epigenetic alteration observed in multiple cancers. Acute myeloid leukemia (AML), a prominent form of hematopoietic cancer, is characterized by abnormal proliferation and differentiation of myeloid progenitor cells. This study focuses on examining the methylation status of the CpG islands in the DNMT1 and CDX2 promoter ...
