Association of Acute Lymphoblastic Leukemia and MDR1 Gene Polymorphism in an Ethnic Iranian Population

نویسندگان
Nejat Shokouhi, Amireh ID 1
Entezari Heravi, Reza ID 2
Esmaeili, Habibollah ID 3
Khedri, Azam ID 4
Behravan, Javad ID 5
Miladpour, Behnoush ID 6
Shirdel, Abbas ID 7
Banihashem, Abdollah ID 8

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چکیده

Background: The frequency of the multi-drug resistance 1 (MDR1) gene C3435T polymorphism differs in various ethnical populations such as Asian, African, and Caucasians populations. A silent C3435T polymorphism in exon 26 of MDR1 has been reported to be associated with a decreased expression of P-gp in TT genotypes carriers compared with CC genotypes ...

کلیدواژه‌ها
p-glycoprotein, multi-drug resistance, acute lymphoblastic leukemia, polymorphism