Methylation Status of SMG1 Gene Promoter in Multiple Myeloma

نویسندگان
Gholipour, Hamid ID 1
Maali, Amirhosein ID 2
Azad, Mehdi ID 3
Abroun, Saeid ID 4
Noruzinia, Mehrdad ID 5
Ghaffari, Sasan ID 6

1 Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

2 Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

3 Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

4 Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

5 Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

6 Hematology Department, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran

doi
چکیده

Background: Epigenetic modifications, such as methylation can occur in multiple myeloma. SMG1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. In this study, we identified the methylation status of the SMG1 gene promoter in patients ...

کلیدواژه‌ها
Multiple Myeloma, DNA methylation, SMG1 gene