Methylation Dynamics of the PPAR Gamma (PPARγ) Gene during Adipogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

نویسندگان
Kaviani, Saeid ID 1
Mohammadi, Mohammad Hossein ID 2
Esmaeili, Shadi ID 3
Salahi-Niri, Aryan ID 4
Hamidpour, Mohsen ID 5

1 Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

2 Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

doi
10.61186/ijbc.16.1.67
چکیده

Background:  Epigenetics is crucial in differentiating mesenchymal stem cells (MSCs) into adipocytes. Specifically, DNA methylation, an epigenetic modification, regulates the expression of genes involved in this process. The peroxisome proliferator-activated receptor gamma (PPARγ) gene is a critical player in adipocyte differentiation, with epigenetic changes affecting its expression. Methods: We isolated mesenchymal ...

کلیدواژه‌ها
Peroxisome Proliferator-Activated Receptor-gamma (PPARγ), DNA methylation, mesenchymal stem cells (MSCs), Differentiation